Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Buchler Glossary
Quaternary ammonium salts, especially derived from Cinchona Alkaloids, have become the most privileged class of chiral PTCs.
Asymmetric PTC has been recognized as a “green” alternative to many homogeneous synthetic organic transformations and is nowadays one of the major catalytic principles in the synthesis of chiral molecules.
Its operational simplicity, mild reaction conditions, environmentally friendly reaction procedure, ready availability, easy recovery / reuse and the low toxicity of these catalysts makes it applicable to large-scale synthesis of complex and multi-functionalized organic molecules in industrial processes. In particular, the use of water as a solvent, heavy transition metal-free conditions, and low energy consumption due to employing room temperature or 0 °C as the reaction temperature make phase-transfer catalysis suitable as a sustainable green chemistry.
Further Articles:
Alkynylation
Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...
Allylsilylation
An Allylsilylation is performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...
Aminohydroxylation
The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...
Aromatic System
Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...