Alkylation is the introduction of an alkyl group into an organic compound by substitution or addition. The alkyl group...
Buchler Glossary
Asymmetric Dihydroxylation of olefins is of high synthetic value because it introduces two vicinal hydroxy groups, endowing prochiral olefinic carbon(s) with chirality. Some oxo metal species of high valency, such as permanganate, ruthenium tetroxide, and osmium tetroxide undergo stereospecific cis-dihydroxylation. Among them, the osmium-mediated dihydroxylation is highly chemoselective and can be applied to a wide range of olefins. Thus, osmium-mediated asymmetric dihydroxylation has been extensively studied.
Sharpless and co-workers reported that dihydroxylation was catalytically effected, with good enantioselectivity and remarkable ligand acceleration, when Cinchona Alkaloid ligands based on DHQD or DHQ was used as the chiral auxiliary.
Further Articles:
Alkynylation
Alkynylation is an addition reaction in organic synthesis where a terminal alkyne adds to a carbonyl group to form an...
Allylsilylation
An Allylsilylation is performed between allylsilanes and aldehydes furnishes homo allyl alcohols. Using Cinchona...
Aminohydroxylation
The Sharpless Aminohydroxylation allows the syn-selective preparation of 1,2-amino alcohols by reaction of alkenes...
Aromatic System
Any hydrocarbon or heterocycle with 4n+2 electrons in a fully conjugated cyclic π system is considered to be an...