Aza-Henry, 6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, (2-nitroethyl)cyclopropane, (R)-6-chloro-4-((S)-2-cyclopropyl-1-nitroethyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one, 1-(4-((R)-(benzyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea, 6´-Aminocinchonidine Derivative

Bifunctional Cinchona Alkaloid Thiourea Catalyzed Highly Efficient, Enantioselective Aza-Henry Reaction of Cyclic Trifluoromethyl Ketimines: Synthesis of Anti-HIV Drug DPC 083.

Reaction Category:

Aza-Henry | Henry

Educt:

6-chloro-1-(4-methoxybenzyl)-4-(trifluoromethyl)quinazolin-2(1H)-one, (2-nitroethyl)cyclopropane

Product:

(R)-6-chloro-4-((S)-2-cyclopropyl-1-nitroethyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one

Catalyst:

1-(4-((R)-(benzyloxy)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)quinolin-6-yl)-3-(3,5-bis(trifluoromethyl)phenyl)thiourea

Cas No:

882166-37-2

DOI Number:

10.1002/anie.201105970

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Associated Product from Buchler GmbH:

6´-Aminocinchonidine Base

Cas No:

2143936-34-7